" " Weird Symptoms of Vitamin D Deficiency



Weird Symptoms of Vitamin D Deficiency

Cholesterol is converted into Vitamin D in the body when the skin is exposed to the sun. Vitamin D is found in higher proportions in certain foods, such as fish fat and dairy products such as cream cheese, but it is difficult to get enough vitamin D through natural diet alone.

weird symptoms of vitamin d deficiency

This Article includes following:

    What is Vitamin D Deficiency

    Vitamin D Deficiency Symptoms

    8 Major Symptoms of Vitamin D Deficiency

    How Vitamin D Deficiency is Treated

    Question and Answer 

Vitamin D is a very important vitamin that has a very responsive effect on the system in the body.

Unlike other vitamins, vitamin D acts like a hormone-like hormone, and every cell in our body has receptors to which it responds.

Cholesterol is converted into vitamin D in the body when the skin is exposed to the sun.

Vitamin D is found in higher proportions in certain foods, such as fish fat and dairy products such as cream cheese, but it is difficult to get enough vitamin D through natural diet alone.

The recommended daily intake (RDI) of the United States is usually around 400-800 IU, and the official recommended intake (RDI) of vitamin D3 for general use is 200 I.U. (5 micrograms)

However, many experts suggest that the intake should be increased, and the current recommended intake is still under discussion.

Vitamin D deficiency is common. It is estimated that about 1 billion people worldwide have low levels of the vitamin in their blood.

According to surveys conducted by Shin Kong Hospital, Wanfang Hospital, and Shuanghe Hospital in Taiwan, 51% of school-age children and adolescents are vitamin D deficient, and 90.3% are vitamin D insufficient. (Data source ILSI Taiwan Document)

Long-term vitamin D deficiency may have the following eight symptoms:

Often get sick or infected

Fatigue and tiredness

Lower back or back pain

Depression or low mood

Slow wound healing

Bone loss

Increased hair loss

Muscle pain

Here are 8 Symptoms of Vitamin D Deficiency Explained

1. Vitamin D deficiency may make you prone to illness or infection

One of the most important roles of vitamin D is to maintain the performance of the immune system, enabling the body to fight viruses and bacteria more effectively.

If you get sick frequently, especially colds or flu, a vitamin D deficiency is very likely a factor.

Several large observational studies have shown a strong relationship between vitamin D deficiency and respiratory infections, colds, bronchitis, and pneumonia.

A number of studies have found that daily intake of vitamin D supplements in doses of up to 4,000 IU reduces the risk of developing respiratory infections.

Vitamin D deficiency is present in many patients with chronic obstructive pulmonary disease (COPD), and in a study of COPD patients with chronic lung disease, patients who were severely deficient in vitamin D had a significant benefit after consuming high-dose supplements for one year, with a significant reduction in acute exacerbations.

Vitamin D is very important and play vital role in immune function. One of the most common symptoms of deficiency is an increased risk of disease or infection.

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2. Vitamin D Deficiency May Cause Fatigue and Tiredness

Tiredness can have many causes, and vitamin D deficiency could be one of them. Fatigue is also a symptom that is often overlooked.

Case studies have shown that low levels of vitamin D can lead to fatigue, with serious negative effects on quality of life.

In a case study of narcolepsy, the patient was chronically deficient in vitamin D due to narcolepsy, and her blood concentration of vitamin D was only 5.9 ng/ml (lower than 20 ng/ml was judged as vitamin D insufficiency). The patient also suffers from chronic headaches and fatigue. When taking vitamin D supplements, her concentration increased to 39ng/ml and symptoms such as tiredness and fatigue improved significantly.

However, even if blood levels of vitamin D are not ultra-low, it may still affect the body's fatigue level.

An observational study was conducted to investigate the relationship between vitamin D and fatigue in young women. The study found that women with blood levels below 20 ng/ml or 21-29 ng/ml were more likely to experience fatigue than women with blood levels above 30 ng/ml.

Another observational study of female nurses found a strong link between low vitamin D levels and fatigue. What's more, researchers found that 89 percent of nurses were vitamin D deficient.

Excessive fatigue and tiredness may be a warning sign of vitamin D deficiency. Supplements can be taken in moderation to boost vitality.

3. Vitamin D deficiency may lead to bone and back pain

Vitamin D is also essential to maintain bone health in following ways.

First, Vitamin D improves the body's absorption of calcium.

Aching bones and lower back pain may be signs of insufficient vitamin D levels in the blood. There are many observational studies that have found an association between vitamin D deficiency and chronic low back pain.

In a study that looked at vitamin D levels in more than 9,000 older women, vitamin D deficiency was significantly associated with back pain. Researchers have found that those who are vitamin D deficient are prone to back pain, including severe back pain.

In one controlled study, people with D deficiency were nearly twice as likely to have bone pain in the legs, ribs, or joints compared with people whose vitamin D was within the normal range.

Low levels of vitamin D in the blood can be a cause of bone and lower back pain.

4. Vitamin D deficiency may lead to depression

Depression can also be a sign of vitamin D deficiency.

In review studies, scientific data have demonstrated a strong association between vitamin D deficiency and depression, especially in older age groups.

Several controlled studies have shown that giving vitamin D to people who are vitamin D deficient can help improve depression, including seasonal depression that occurs during the colder months.

Depression has been linked to low levels of vitamin D in the body, and some studies have found that vitamin D supplements can improve mood.

5. Vitamin D deficiency may lead to impaired wound healing

Slow wound healing after surgery or injury could be a sign that you have low levels of vitamin D in your blood.

The results of the test-tube study confirmed that vitamin D is important for the production of new skin-forming compounds. This whole experimental phase is an important part of wound healing.

A study of patients undergoing dental surgery found that vitamin D deficiency impairs healing.

It has also been suggested that vitamin D's role in controlling inflammatory responses and fighting infection is important for proper healing.

In an analysis of patients with diabetic foot infections, it was found that those severely deficient in vitamin D were more prone to inflammatory markers that could compromise healing.

However, there is little research on the effect of vitamin D supplementation on wound healing in deficient patients.

One such study found that when vitamin D-deficient patients with leg ulcers were treated with the vitamin, ulcer size was reduced by an average of 28%.

Vitamin D deficiency may lead to poor wound healing after surgery, injury, or infection.

6. Vitamin D Deficiency May Cause Bone Loss

Vitamin D plays a vital role in calcium absorption in body.

Many older adults diagnosed with bone loss believe they need to get more calcium. However, they may also be deficient in vitamin D.

Low bone density indicates that your bones have lost calcium and other important minerals. This makes older people, especially women, more prone to fractures.

In a large observational study of more than 1,100 postmenopausal, middle-aged women, researchers found a strong relationship between low vitamin D and low bone density.

However, a controlled study found no improvement in bone mineral density in vitamin D-deficient women who took high-dose supplements, even though blood levels improved.

Regardless of these findings, getting enough vitamin D and maintaining blood levels within an optimal range is currently the best way to protect bone quality and reduce fracture risk.

A diagnosis of low bone density may be a sign of vitamin D deficiency. Getting enough vitamins is important for maintaining bone density as we age.

7. Vitamin D Deficiency May Cause Hair Loss

Common causes of hair loss are often attributed to stress.

However, when hair loss is severe, it can be the result of disease or nutritional deficiencies.

Hair loss in women is associated with low vitamin D concentrations, although this has not been studied enough to date.

Alopecia areata, commonly known as "ghost shaved head", is an autoimmune disease characterized by severe hair loss on the head and other parts of the body. It has been linked to rickets, a disease of cartilage in children due to vitamin D deficiency.

Low vitamin D concentrations have been associated with alopecia areata and may be a risk factor for its onset.

A study of people with alopecia areata showed that low blood levels of vitamin D tended to lead to more severe hair loss.

In one case study, researchers successfully treated hair loss in a young boy who lacked vitamin D receptors. The treatment modality used is topical application of a synthetic form of vitamin D.

Hair loss may be a sign of vitamin D deficiency in autoimmune alopecia areata.

8. Vitamin D Deficiency May Cause Muscle Pain

The cause of muscle pain is often difficult to determine.

Evidence suggests that vitamin D deficiency may be an underlying cause of muscle pain in both children and adults.

In one study, 71% of chronic pain patients were found to be vitamin D deficient.

Vitamin D receptors are found in nerve cells called nociceptors, which sense pain.


Several studies have found that taking high-dose vitamin D supplements can reduce various types of pain in people with a deficiency.

A study of 120 vitamin D-deficient children with pain found that a single dose of vitamin D reduced pain scores by an average of 57%.

The link between chronic pain and low vitamin D blood levels may be due to interactions between the vitamin and pain-sensing nerve cells.

How is Vitamin D Deficiency Treated?

1. Basic principles and purpose of Treatment

For the treatment of vitamin D deficiency, the treatment plan should be comprehensively considered according to the characteristics of the patient, the condition of the disease, vitamin D preparations and dosage forms, vitamin D detection, and seasons.

In primary care, vitamin D treatment practice should be at the core of any clinical management guidelines; treatment options must be accepted by lay primary care physicians and patients. In order for the patient to cooperate and adhere to the treatment, the complexity of the treatment plan must also be considered, as well as the patient's personal religious and cultural beliefs, such as: whether some preparations contain gelatin, whether vitamin D is derived from animals or plants, and whether the preparations contain allergens.

Primary care physicians should be aware that vitamin D is readily available, at an appropriate price, that formulations are of reliable quality, and that relevant laboratory services are available for monitoring. Treatment of vitamin D deficiency should be effective if given proper assessment, biochemical testing, and good adherence to treatment.

The main goals of treatment in patients with vitamin D deficiency bone disease:

(1) Use sufficient doses to ensure correction of vitamin D deficiency (ideally 25OHD ≥ 50 nmol/L)

(2) Improving the clinical consequences of vitamin D deficiency in a timely manner;

(3) Avoid vitamin D poisoning.

2. Vitamin D3, or Vitamin D2?

At present, different preparations of vitamin D3 and vitamin D2 are used clinically in China and the United States, and in Europe, vitamin D3 is more commonly used clinically; at the same time, the Endocrine Society of North America believes that both vitamin D3 and vitamin D2 can produce better results. But there is much debate about the therapeutic merits of animal-derived vitamin D3 versus plant-derived vitamin D2. Biochemical indicators suggest that vitamin D2 appears to be cleared from tissues more rapidly than vitamin D3 and has lower bioavailability, especially with intermittent bolus administration. In light of this controversy, and the inconsistency in the use of various dosage forms, guidelines for vitamin D2 and vitamin D3 are provided.

Recommendation: Based on the current medical consensus and issues related to 25OHD2 detection, it is recommended that vitamin D3 be the preferred preparation for the treatment of vitamin D deficiency, consistent with the views of the International Osteoporosis Foundation and the British Osteoporosis Society.

3. Oral or intramuscular injection?

Although intramuscular injection can fully attach vitamin D to the body, there are important factors to consider before using it, including its unpredictable bioavailability, slower saturation, and more trouble than oral preparations. Parenteral vitamin D administration is not recommended as a first-line treatment guide, mainly due to significant inter-individual variability in absorption.

Recommendation: Oral vitamin D is recommended.

4. Fixed or titrated dosing?

Titrated dosing strategy is to gradually achieve the desired drug level by administering low doses of the drug. The concentration of 25OHD varies not only by external factors, such as sun exposure and diet, but also by individual characteristics, including genetic factors and body composition; these individual characteristics can also affect the pharmacokinetics and efficacy of subsequent vitamin D supplementation.

Titration therapy has potential benefits in reducing toxicity and improving saturation, allowing for more precise saturation. But consider that it increases costs and complicates physician treatment and patient compliance. Given that there are no studies comparing titration versus fixed-dose therapy, the simpler fixed-dose regimen is preferred.

Recommendation: The recommended treatment method is a fixed loading dose and maintenance therapy.

5. Lower daily dose, or higher intermittent dose?

There is no consensus on the need for and benefits of lower daily doses and higher intermittent dosing regimens. In several comparative studies, one found that intermittent dosing was less readily available in nursing centers and thus less effective; however, the same biochemical effect was achieved when different dosing regimens were administered continuously.

Evidence for lower daily doses is mainly based on clinical trial studies of pharmacological treatments for osteoporosis, however, few of these patients were severely vitamin D deficient, and high-dose daily vitamin D preparations have not been used in community studies. In addition, most studies have only focused on short-term treatment without examining the risks and benefits of long-term, high-dose, intermittent therapy. Domestic related research is still lacking.

Treatment alternatives include a loading phase of high-dose vitamin D3 (or D2) for several weeks, followed by a maintenance phase. The maintenance phase can be supplemented with daily supplementation, or less frequent "top-ups", depending on the patient's needs or desires. There may also be some patients (such as gastrointestinal disorders) who cannot maintain adequate vitamin D levels, so they may need to provide more aggressive replacement or maintenance programs under the guidance of specialist physicians.

It has been suggested in the past that a single large dose of vitamin D (300,000 IU or more) might lead to sustained correction of vitamin D deficiency and avoid reliance on continued regular small-dose supplementation. This recommendation was originally made in the management of rickets and rickets and has also been considered an option in the management of vitamin D deficiency in the elderly, however, more recent recommendations suggest that intermittent high-dose vitamin D administration is ineffective and may actually increase fracture risk.

In the absence of further studies, this single loading dose approach is not recommended; instead, we recommend a divided loading dose followed by a maintenance phase.


(1) When vitamin D deficiency needs to be corrected quickly, such as patients with disease symptoms, or ready to start high-efficiency anti-absorption drug therapy (Zoledronate or Denosumab), the recommended treatment plan is on the basis of a fixed loading dose, followed by regular maintenance therapy;

(2) When correction of vitamin D deficiency is not urgent, or when vitamin D supplementation is accompanied by oral antiresorptive drugs, a maintenance regimen may be possible without loading doses.

6. Calcium Supplementation

When the calcium supplement dose is 400-800 mg/day, its sustainability and effect are poor. A recent meta-analysis suggested that combined calcium and vitamin D supplementation could reduce mortality, whereas vitamin D supplementation alone did not.


(1) In order to protect bone health, it is necessary to advocate adequate intake of dietary calcium, and encourage patients and doctors to use "calcium calculator" (such as http://www.rheum.med.ed.ac.uk/calcium-calculator.php);

(2) If it is found that patients with osteoporosis cannot reliably or regularly consume calcium (at least 700 mg/day), calcium supplementation, or a combination of calcium supplementation and vitamin D is recommended.

7. Example scheme

Regarding the treatment of vitamin D deficiency, different organizations recommend different treatment options. For example, the Endocrine Society of North America recommends that adult patients with vitamin D deficiency be given 50,000 IU of vitamin D3 or D2 once a week for 8 weeks (6,000 IU/day), so that their 25OHD reaches a level above 30 ng/ml, and then maintenance therapy of 1,500 to 22,000 IU/day is carried out.

The Australian and New Zealand Bone and Mineral Society, the Australian Endocrine Society, and the Australian Osteoporosis Society jointly recommend vitamin D 3000-5000 IU/day (75-125 μg) for at least 6-12 weeks in the treatment of moderate to severe vitamin D deficiency. 25OHD concentration should be detected after about 3 months of treatment, and then continued treatment with a lower dose of 1000-2000 IU/day. Choose vitamin D capsules or liquid formulations, while ensuring adequate calcium intake.

When rapid correction of vitamin D deficiency is required, such as when the patient is symptomatic or is about to start treatment with a high-potency antiresorptive drug (Zoledronate or Denosumab), the recommended regimen is a fixed loading dose followed by regular maintenance therapy. The following example protocol is recommended according to the British Osteoporosis Society:

(1) The therapeutic loading for vitamin D deficiency can be up to 300,000 IU, given in weekly or daily splits. The specific plan is based on the availability of local vitamin D preparations. An example plan is as follows:

A 50,000 IU capsule once a week for 6 weeks (300,000 IU).

B 20,000 IU capsules 2 times a week for 7 weeks (280,000 IU).

C 800 IU capsules 5 times daily for 10 weeks (280,000 IU).

(2) The maintenance regimen can be given 1 month after the loading dose is supplemented. The maintenance dose is 800 to 2000 IU per day (occasionally up to 4000 IU per day); higher doses may be given daily or at intervals, but the total maintenance dose is the same.

It should be understood that vitamin D is taken with food to aid absorption; vitamin D in loading regimens should not be derived from calcium/vitamin D combinations, which can lead to overdosage of calcium.

The following methods of administration have proven ineffective, or are ineffective and have an increased risk of toxicity, and are therefore not recommended: Annual reserve dosing of vitamin D by intramuscular or oral administration; use of active vitamin D preparations (calcitriol and alfacalcidol).

Monitoring Purpose

Clinicians should be aware that vitamin D treatment can reveal undiagnosed primary hyperparathyroidism. While the above dosing regimens are unlikely to result in toxicity, it should be recognized that certain populations may be at increased risk for toxicity or adverse reactions and should be monitored for this. It is often monitored by measuring corrected serum calcium levels.

Corrected total blood calcium (mg/dL) = measured total blood calcium (mg/dL) + 0.8 x [4.0 - serum albumin concentration (g/dL)].

Genetic abnormalities in vitamin D metabolism, or comorbidities such as chronic kidney disease, granulomatosis, or hyperparathyroidism, can predispose patients to increased susceptibility to vitamin D therapy. This phenomenon can be seen as the number of treated cases increases, such patients need to be identified, and subsequent dose reductions may be required. Surveillance is part of the recommended regimen and the need for repeat testing may vary by regimen.

Evidence is scant regarding when to monitor response to treatment, but the goals of monitoring include: detection of vitamin D deficiency in patients who persist after loading doses; detection of vitamin D deficiency in patients during maintenance therapy; detection of subclinical primary hyperparathyroidism in patients on vitamin D therapy.

1. Assessment of improvement in 25OHD status in alternative therapy

The dose-response of vitamin D supplementation varies widely across studies. Related confounding factors such as summer UV exposure were an important reason for the inconsistent results. When limited to vitamin D supplementation for winter 25OHD.

Question and Answer

What are the symptoms of low vitamin D deficiency?

Following are the common symptoms of low level of Vitamin D Deficiency

Often get sick or infected

Fatigue and tiredness

Lower back or back pain

Depression or low mood

Slow wound healing

Bone loss

Increased hair loss

Muscle pain

What happens if you are severely deficient in vitamin D?

Vitamin D deficiency can lead to decreased bone density, which can lead to osteoporosis and fractures (fractures). Severe vitamin D deficiency may also lead to other diseases. In children, it can cause rickets. Rickets is a rare disease that causes bones to soften and bend.

What happens if you are severely deficient in vitamin D?

Vitamin D deficiency can lead to decreased bone density, which can lead to osteoporosis and fractures (fractures). Severe vitamin D deficiency may also lead to other diseases. In children, it can cause rickets. Rickets is a rare disease that causes bones to soften and bend.

Is Low Vitamin D a Cause for Concern?

Vitamin D is essential for strong bones and Vitamin D absorption required necessary sufficient quantity of calcium to be exist in the body. Vitamin D deficiency has traditionally been associated with rickets, a disorder in which bone tissue does not mineralize properly, resulting in soft and deformed bones.

What Cancers Can Low Vitamin D Cause?

Vitamin D deficiency has been linked to various cancers, including prostate cancer, multiple myeloma, colorectal cancer, and breast cancer.

Is low vitamin D an emergency?

When rickets is very severe, it can cause low calcium levels in the blood. This can cause muscle spasms, spasms, and difficulty breathing. These require emergency treatment in a hospital. Rarely, very low vitamin D levels can lead to weakening of the heart muscle (cardiomyopathy).

Could you be hospitalized for low vitamin D?

With severe vitamin D deficiency, the odds of hospitalization were 4.57 (95% CI 1.83, 11.4) (P = 0.001).

What causes vitamin D to drop?

Certain chronic diseases like Cystic fibrosis, Crohn's disease, and celiac disease, for example, reduce the gut's ability to absorb enough vitamin D into the bloodstream, resulting in low circulating levels of vitamin D, which means less vitamin D is available to different parts of your body.

What are the symptoms of vitamin D deficiency?

Bones become soft, leading to skeletal deformities, short stature, dental problems, weak bones, and pain when walking. Researchers are studying whether other symptoms or conditions, such as depression, bone pain and weakness, can be caused by low vitamin D levels.

Does Vitamin D Affect Sleep?

Research shows that vitamin D has a vital role in sleep regulation. Vitamin D deficiency is associated with sleep difficulties and make shortened the sleep duration.

How long does it take to recover from vitamin D deficiency?

How much vitamin D do I need daily? Besides getting outside in the sun, there are two ways to boost your vitamin D levels: eating vitamin D-rich foods and supplements. "Adding an over-the-counter vitamin D supplement can make improvements in as little as three to four months.

Can Low Vitamin D Cause Neurological Symptoms?

As summarized in Figure 1, vitamin D deficiency is mechanistically and clinically associated with neurologic and neuropsychological disorders, cognitive impairment, and neurodegenerative diseases.

Which fruit is rich in vitamin D?

Oranges are one of the vitamin D-rich fruits because their juice is fortified with calcium and vitamin D. This is one of the best sources of vitamin D for people who are lactose intolerant and cannot include milk and dairy products in their diet.

What does low vitamin D mean for women?

Vitamin D deficiency occurs when the body does not get enough vitamin D from sunlight or diet. Vitamin D deficiency can lead to loss of bone density, osteoporosis and fractures. Vitamin D is sometimes called the sunshine vitamin because your body makes vitamin D from cholesterol when your skin is exposed to sunlight.

Can Vitamin D Deficiency Cause Weight Gain?

Research on Vitamin D deficiency has shown that it is cause to weight gain and also may cause other health related complications, which needs to be treated wisely and attentively. You can maintain adequate vitamin D levels through limited sun exposure, a diet rich in vitamin D, and taking vitamin D supplements.

What snacks are high in vitamin D?

Get the recipe for Rainbow Trout with Apple Pearls and Riesling Butter Sauce. mushroom. Mushrooms are a delicious source of vitamin D and also provide several B vitamins and potassium. ... egg yolks ... canned tuna. sardines ... Swiss cheese ... Supplement 101: Vitamin D.

Which drink is high in vitamin D?

Orange juice tops the list of vitamin D-rich beverages, along with a host of other nutrients. It is recommended not to buy orange juice from the market, but to make it at home.

Are Bananas High in Vitamin D?

No, there is no vitamin D here. But bananas do contain a lot of magnesium. guess what? One of the many reasons you need magnesium is to make your vitamin D work once it enters your bloodstream, making it a must for you to reap the many benefits of vitamin D.

Does Vitamin D Deficiency Make You Feel Weird?

Vitamin D can also affect your mood. You may experience symptoms of depression due to low energy levels. Studies also show that vitamin D supplementation can also help you fight symptoms of depression.

How can I increase my vitamin D fast OR How long does it take to get your vitamin D levels up?

Vitamin D3 supplements are thought to raise blood levels of vitamin D for about 24 hours. However, it takes up to seven days for this to be converted into the active form of vitamin D -- which is what the blood test will find.

What blocks vitamin D absorption?

Therefore, diseases that affect the gut and digestion, such as celiac disease, chronic pancreatitis, Crohn's disease, and cystic fibrosis, can reduce vitamin D absorption.

Does vitamin D give you energy?

New research from Newcastle University has shown that vitamin D is essential for making our muscles work efficiently and boosting energy levels.

Can Low Vitamin D Cause Leukemia?

People who live at higher latitudes have twice the incidence of leukemia, have lower sun exposure, and are more likely to be vitamin D deficient, according to findings from a study recently published in PLOS One.

Which autoimmune diseases can cause low vitamin D levels?

Low vitamin D levels have been linked to autoimmune diseases such as Hashimoto's disease, hypothyroidism multiple sclerosis, type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis, and even Parkinson's disease.

How long does it take to see a change in vitamin D levels?

Once a new vitamin D supplement dose has been determined and incorporated into the routine, it is recommended to wait at least 2-3 months before testing in order to accurately reflect the resulting 25(OH) vitamin D serum levels.

How Do Vitamin D Levels Change Rapidly?

One study showed that after taking large doses of vitamin D3, it took about seven days to convert and cause 25(OH)D levels to peak.


Vitamin D deficiency is very common, and many people are unaware of its importance.

Symptoms of vitamin D deficiency are often nonspecific, which means it is difficult to know whether the symptoms are caused by low vitamin D or another factor.

If you think you may be deficient, be sure to check with your doctor and have your blood vitamin D levels measured. Vitamin D deficiency can be easily fix and increase the level.

You can increase your sun exposure and eat foods rich in vitamin D, such as fish or dairy products. Various vitamin D supplements are also available in the market.

Fixing a vitamin D deficiency is easy and has great health benefits.